Target+-+serine+threonine+protein+phosphatase+5+(T.+brucei)

http://www.tdrtargets.org/targets/view?gene_id=19618 http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.1.3.16&Suchword=&organism[]=Trypanosoma+brucei&show_tm=0 []
 * Target (protein/gene name): serine threonine protein phosphatase 5**
 * Protein ID (NP or XP #):** Tb927.10.13670
 * Organism: trypanosoma brucei**
 * Etiologic Risk Group (see link below): Risk 2**
 * Background/Disease Information:**
 * Trypanosoma brucei is the protozoa that is the cause for the parasitic disease African trypanomiasis. This disease can infect both humans and animals, and is characterized by fever and headaches, until the lymphatic and circulatory systems become affected. The disease then progresses rapidly and has a variety of manifestations including severely disrupted sleep cycles due to the parasite passing through the blood brain barrier, anemia, endocrine malfunctions, cardiac problems and kidney dysfunctions.**
 * Druggable Target: A similar target has been used in successful runs by the study alsford, and the TDR gives it a druggability index of 0.5. It displays some similarity to a human, but not an exact match with 49% similarity on a 98% query coverage.**
 * Essentiality:**
 * *EC#: 3.1.3.16 **
 * Link to BRENDA EC# page:**
 * Enzyme Assay information:**

[]

Homology Model option: Show pairwise alignment of your BLASTP search in NCBI against the PDB Query Coverage: 98% Max % Identities: 49% % Positives: 68
 * Structure Available (PDB or Homology model)**

[] microcystin-Sepharose bead chromatography []
 * Current Inhibitors: Only 5 hits were found in the binding database, the top hit being CHEMBL318778.**
 * Expression Information: The protein is usually expressed via its natural protozoa, but has been cloned and characterized from e.coli before.**
 * Purification Method:**
 * Image of protein:**

Cartoon image of 1WAO, the closest protein resembling the chosen target. [] [] MAGVEEADKLKQLGNAAFSERKWHLAIDMYTKAIELTKTPTLFCNRALAELRAELPGAAL ADADAALGIEPTFAKAYYHKASAYLSLGKHKQALTNYKKVVDLAPQNSDAQAKVEFCKKE IRRINFENAIMTPDEAPLSQTIKLGSVRADYDGPRIENETVTVEFVEAMKEHFRLEKLID RHDVIFILLEVQKILKKCPNFVSINVPVGEEITVCGDTHGQYYDLLNIFKLNGNPLETNR YLFNGDFVDRGSYSFENIMTLFAYKVLYPDHFFLSRGNHEGVSMNRMYGFEGEVTQKYNS EMFRLFTEVFNSLPIGHIINNEVFVVHGGLYSSDKVTLDDLQHPNRFRDIPESGLICESL WSDPQPMPGRAPSKRGVSCLSFGPDVTETFLNNNNLKLLVRSHEVKDEGYEIEHGGKCIT VFSAPNYCDQMGNKGAFIRFTGGDMKPRFTTFTHVPHPGKRPMHYATGFGLF
 * Amino Acid Sequence:**

53312.7 38320
 * length of your protein in Amino Acids: 472**
 * Molecular Weight of your protein in kiloDaltons using the [|Expasy ProtParam]website:**
 * Molar Extinction coefficient of your protein at 280 nm wavelength:**
 * TMpred graph Image ** (@http://www.ch.embnet.org/software/TMPRED_form.html).
 * CDS Gene Sequence (paste as text only):**
 * GC% Content for gene:**
 * CDS Gene Sequence (codon optimized) - copy from output of Primer Design Protocol (paste as text only):**
 * GC% Content for gene (codon optimized):**