SungHoonPark_ResearchPage_Summer2017

Target: protein phosphatase 2B, putative Organism: //T. brucei // Overlap Primers Designer: N/A Prefix IDT Ordering (yellow = ordered): N/A Forward Tail Primer in 5' to 3' Orientation: N/A ReverseTail Primer in 5' to 3' Orientation: N/A Diease/Relevance: Trypanosoma brucei is a species of parasitic kinetoplastid. It is the cause of a vector-borne disease of vertebrate animals, including humans, carried by genera of tsetse fly in sub-Saharan Affrica. In humans, T. brucei causes African trypanosomiasis, or sleeping sickness. T. brucei is transmitted between mammel hosts by an insect vector belonging to different species of tsetse fly. Type: Phosphatase E.C.: 3.1.3.16 Structure: There is no model available for this protein in Modbase. There is no structure available for this protien in the PDB. Homologous Structure: N/A Transmembrane Region: 0 Complex: No Activity: phosphorylated Hsp90 + H2O = Hsp90 + phosphate; PP5 positively regulates the function of Hsp90 to maintain cellular homeostasis during proteotoxic stresses Assay: Assay for Calcineurin (3.1.3.16); Source: Sigma-Aldrich; Description: Automatic link to known assays based on EC numbers. Assay: Assayed; Source: BRENDA; Description: An enzyme with this EC number or name or sequence has been assayed in Trypanosoma brucei. Essentiality:  Tb09.160.0480 has essentiality data  Gene/Ortholog: Tb09.160.0480 (OG4_30044); Phenotype: significant loss of fitness in bloodstream forms (3 days); Source study: alsford  Gene/Ortholog: Tb09.160.0480 (OG4_30044); Phenotype: no significant loss or gain of fitness in bloodstream forms (6 days); Source study: alsford  Gene/Ortholog: Tb09.160.0480 (OG4_30044); Phenotype: no significant loss or gain of fitness in procyclic forms; Source study: alsford  Gene/Ortholog: Tb09.160.0480 (OG4_30044); Phenotype: significant loss of fitness in differentiation of procyclic to bloodstream forms; Source study: alsford Druggability: 0.8 <span style="background-color: #ffffff; font-family: arial,sans,sans-serif;">TDR Target Link: www.tdrtargets.org/targets/view?gene_id=11011 <span style="background-color: #ffffff; font-family: arial,sans,sans-serif;">Gene (Not gene ontology): GeneDB / Tb09.160.0480 Substrate Availability: N/A Supplier: N/A Second Substrate: N/A Number of Inhibitors: N/A Known Inhibitors: N/A Notes B: N/A