Trypanosoma+Brucei+dihydroorotate+oxidase

**Target (protein/gene name):** Typanosoma brucei brucei, **dihydrooroate oxidase**


 * NCBI Gene # or RefSeq#: **NT_165288.1


 * Protein ID: **2B4G


 * E.C Number: **1.3.98.1


 * Organism: **Trypanosoma brucei brucei


 * Etiologic Risk Group: **n/a

The parasitic protozoan Trypanosomabrucei is the causative agent of human African trypanosomiasis (sleeping sickness) and nagana. Sleeping sickness is caused by infection with protozoan parasites. The parasite is transmitted to humans through the bite of the tsetse fly. The disease was brought under control in the mid-1960s through intensive control programmes, but re-emerged due to weakened surveillance, reaching epidemic proportions in several regions by 1970. Current drug therapies have limited efficacy, high toxicity and/or are continually hampered by the appearance of resistance. Antimicrobial peptides have recently attracted attention as potential parasiticidal compounds.
 * Disease Information: **

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Dihydroorotate dehydrogenase EC 1.3.5.2 (previously 1.3.99.11) is a flavoenzyme that catalyzes the oxidation of <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|(//S//)-dihydroorotate] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;"> to <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|orotate] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;"> with the reduction of <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|FMN] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;"> to <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|FMNH2] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">, a key reaction in the //<span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">de novo //<span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;"> pyrimidine biosynthetic pathway ([ <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|Fagan06] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">] and reviewed in [ <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|Loffler15] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">]). It is a Class 2 enzyme that utilizes <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|a ubiquinone] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;"> as the electron transfer quinone and is coupled to the mitochondrial respiratory chain [ <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|Fang13a] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">, <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|Hines86] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">]. In mammals the enzyme is an integral membrane protein found on the outer surface of the mitochondrial inner membrane, exposed to the intermembrane space [ <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|Rawls00] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">]. It contains a serine residue that functions as the active site base during catalysis [ <span style="background-color: #ffffff; color: #01549f; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[|Jiang00a] <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">]. <span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">Inhibitors of human dihydroorotate dehydrogenase are of interest in drug development.
 * Enzyme Information:**

<span style="background-color: #ffffff; color: #333333; font-family: arial,helvetica,clean,sans-serif; font-size: 14px;">[]



The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. Formerly Ec 1.3.3.1.
 * Comment:**

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<span style="background-color: #ffffff; color: #333333; font-family: &#39;Helvetica Neue&#39;,Helvetica,Arial,sans-serif; font-size: 14px;">Nucleotide biosynthesis pathways have been reported to be essential in some protozoan pathogens. Hence, we evaluated the essentiality of one enzyme in the pyrimidine biosynthetic pathway, dihydroorotate dehydrogenase (DHODH) from the eukaryotic parasite Trypanosoma brucei through gene knockdown studies. RNAi knockdown of DHODH expression in bloodstream form T. brucei did not inhibit growth in normal medium, but profoundly retarded growth in pyrimidine-depleted media or in the presence of the known pyrimidine uptake antagonist 5-fluorouracil (5-FU). These results have significant implications for the development of therapeutics to combat T. brucei infection.
 * Essentiality: **

<span style="background-color: #ffffff; color: #333333; font-family: &#39;Helvetica Neue&#39;,Helvetica,Arial,sans-serif; font-size: 14px;">[]

BRENDA Page: []

Enzyme Image:
 * <span style="color: #333333; font-family: &#39;Helvetica Neue&#39;,Helvetica,Arial,sans-serif; font-size: 14px;">Total Structure Weight: 141591.70
 * <span style="color: #333333; font-family: &#39;Helvetica Neue&#39;,Helvetica,Arial,sans-serif; font-size: 14px;">Atom Count: 9849
 * <span style="color: #333333; font-family: &#39;Helvetica Neue&#39;,Helvetica,Arial,sans-serif; font-size: 14px;">Residue Count: 1268
 * <span style="color: #333333; font-family: &#39;Helvetica Neue&#39;,Helvetica,Arial,sans-serif; font-size: 14px;">Unique protein chains: 1

**TDR Target page: []**

Druggability Index: 0.9
 * Associated Compounds and Druggability:**
 * By orthology to known druggable targets:
 * Homo sapiens: [] Compounds: []
 * Mus musculus: [] Compounds: []
 * Rattus norvegicus: [] Compounds: []
 * Plasmodium falciparum: []Compounds: []

<span style="background-color: #ffffff; font-family: arial,helvetica,clean,sans-serif; font-size: 13.52px;">Dihydroorotate oxidases have been highly purified from the parasitic protozoa Crithidia fasciculata and Trypanosoma brucei. The Crithidia enzyme was purified 4200-fold from a crude soluble protein extract in four steps. The protein is a dimer as judged from the native (Mr 60 000) and subunit (Mr 32 700) molecular weights. The purified enzyme exhibits a characteristic flavin electronic spectrum, and each mole of native dimer contains 1.0 mol of tightly bound flavin mononucleotide. Under anaerobic conditions, the flavin chromophore is reduced upon addition of L-dihydroorotate. In air-saturated buffer, the enzyme catalyzes the conversion of L-dihydroorotate to orotate with concomitant reduction of equimolar amounts of molecular oxygen to hydrogen peroxide.
 * Assay and Expression Information:**

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 * Assay method:
 * <span style="background-color: #ffffff; color: #ff0000; font-family: Arial,Helvetica,Verdana,sans-serif; font-size: 9pt;">[|ChEMBL_415083 Inhibition of Trypanosoma brucei brucei recombinant 24-SMT][|Inhibition Assay The DHO-catalyzed hydrolysis of dihydrooroate was monitored spectrophotoetrically at 230 and 280 nm using a SPECTRAmax (Molecular Device) plate reader.]


 * [|Inhibition Assay The DHO-catalyzed hydrolysis of dihydrooroate was monitored spectrophotoetrically at 230 and 280 nm using a SPECTRAmax (Molecular Device) plate reader.]

There are no<span style="font-family: &#39;Times New Roman&#39;,serif; font-size: 11pt;"> transmembrane regions

<span style="background-color: #ffffff; font-family: &#39;Times New Roman&#39;,Times,serif;">TMpred graph Image ([])

<span style="background-color: #ffffff; font-family: &#39;Times New Roman&#39;,Times,serif;">


 * Gene Available:** Yes []

code <span style="background-color: #ffffff; font-family: monospace,serif;">>NT_165288.1:1543092-1543844 Trypanosoma brucei brucei TREU927 chromosome 11 chr11_scaffold01 genomic scaffold, whole genome shotgun sequence ATGTCCAAGCCACAACCCATCGCAGCAGCCAACTGGAAGTGCAACGGCTCCCAACAGTCTTTGTCGGAGC TTATTGATCTGTTTAACTCCACAAGCATCAACCACGACGTGCAATGCGTAGTGGCCTCCACCTTTGTTCA CCTTGCCATGACGAAGGAGCGTCTTTCACACCCCAAATTTGTGATTGCGGCGCAGAACGCCATTGCAAAG AGCGGTGCCTTCACCGGCGAAGTCTCCCTGCCCATCCTCAAAGATTTCGGTGTCAACTGGATTGTTCTGG GTCACTCCGAGCGCCGCGCATACTATGGTGAGACAAACGAGATTGTTGCGGACAAGGTTGCCGCCGCCGT TGCTGCTGGTTTCATGGTTATTGCTTGCATCGGCGAAACGCTGCAGGAGCGTGAATCAGGTCGCACCGCT GTTGTTGTGCTCACACAGATCGCTGCTATTGCTAAGAAACTGAAGAAGGCTGACTGGGCCAAAGTTGTCA TCGCCTACGAACCCGTTTGGGCCATTGGTACCGGCAAGGTGGCGACACCACAGCAAGCGCAGGAAGCCCA CGCACTCATCCGCAGCTGGGTGAGCAGCAAGATTGGAGCAGATGTCGCGGGAGAGCTCCGCATTCTTTAC GGCGGTTCTGTTAATGGAAAGAATGCGCGCACTCTTTACCAACAGCGAGACGTCAACGGCTTCCTTGTTG GTGGTGCCTCACTGAAGCCAGAATTTGTGGACATCATCAAAGCCACTCAGTGA
 * CDS Gene Sequence:**

code

code <span style="background-color: #ffffff; font-family: monospace,serif;">>XP_828627.1 triosephosphate isomerase [Trypanosoma brucei brucei TREU927] MSKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVVASTFVHLAMTKERLSHPKFVIAAQNAIAK SGAFTGEVSLPILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVAAGFMVIACIGETLQERESGRTA VVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILY GGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKATQ code code <span style="background-color: #ffffff; font-family: monospace,serif;">>NC_000016.10:72008744-72025417 Homo sapiens chromosome 16, GRCh38.p12 Primary Assembly GGGCTTAATGACGGAAGGAGCATGGCGTGGAGACACCTGAAAGTGAGTCCCGCGAGTGAGCAGTGTGGAT GGGGGACCAGGGACCGGGGAGGGCGAGAACGGAGAGTCAGGCCGGGCGAGGCATGGACCGAAGGCGGCTC CGGGAGTGTGGGCCCCCCTGGGACGTGTGCGTGTTTCCGGGGTCTCCTGCAAATGCTCGTGCGTGTGCAT TTGCACGTGGACTCGGTCAGGCGTGTGCAGACAGCGCCTGCAGGTCTGGGTGGGTGCTGATCTGAGTGTC TGCGCCTGGGCCATGTTTTTGAGCCTGGCACAGGGGTGCTTAGTGAACACATGACCGCCTAGCGTTGTGT GCCGGATCCAACGGGGAATGAAACTAGAGTAGGACATGCTCCCAACCCTTTTAGGTAAAGTTTTGTTAGG GGCGGGGGTCTCTGTGAAAAGTTCTTAGCTGTATCCCCGTATGTAATAGGTGTTCAGAGGCCGGGCGCGG TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGATCGAGA CCATCCTGGCTAACAAGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGCGGTGGCGG GCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAAGCGGAGCTTGC AGTGAGCCGAGATTGCGCCACTGCAGTCCGCAGTCCGGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAA AAAAAAAAAAAAAAAAAAAAAATAGGTGTTCAGATATTTGTTGATTGACATGGTGGGGGGGAGTACAGTC TCCAAGGGAGGCAATGAATAACCTTGACTTTCTTTTTATATGTTTATTTGAGACGGAGTCTTGGGCTGTC GCCCAGGCTGGAGTGCAGTGGCGCGATCTTGGCTCACTGCAACCTCCGCCTCCCGGGTTCAACCGATTTT CCTGCCTCGGCCTCCTGCGTAGCTGAGATTACAGGCGCGCGCCACCACGACTGGCTAATTTTGGTATTTT TAGTAGAGACTGCAGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTCACCTCGTGAGCCTCCCAAA GTGCTGGGATTACTGGCGTGAGCCACCGCGCTCGGCCTGAGTCTCTTTTTAAAATAAATAAATGGAGAGA GATGGGATCTCACTGTGTTGCCCAGGCTGGTCTAGAACTATTGGCCTCAAGGGATCTTCCCGCCTCAGCC TCCCAAAGTGGTGGGATTACAGGCGTGGGCTACCGCGCCCAGCCAATGAATACTTGATCTACATGTCTTT AGCAGTTTGGAAGGATCCTTAAAAGCAAATCTAATCATGTCATTTCCTGGCTTAGGGAACAAAACCCAAA TCTTTATTTTGGCCAAGACTCCTGCTCCTTTCTCCTGCCTCGTCTTAAGCCTTACTTTCCCTCACTCCTC TGTTCCAAACTTTCTCCCTTTTTCATTCTCTTCTGCTACTGAGAGAGCCTTTACACTTTTTCCTCTCCGT ACTGCCTTCTGGTTAACTATTTTTTTAAATAATTGAACCAGAATAGGTTCAGAGAGACCCCCATCAACTC GTTTATCCCTTGAGTATCAGCTTTAAGTCATTTCCTTAAGGAAGCCTTTCCTTACCTCTAAGATTAGGTT GAATACTTCCATTACCTTATACTTTTTATCCTTCATCACAGTTGCTATGACTACATATTTGCATGATCAT TAATTTCTGTCTGTCGCTTCATAAGATCACACTCTCCATGAGGGTAGGGGCAAGATCTGTTTTGTCATCT TTGCTCAATCAGTATTTGATGAATGACTGAACTAATGAATGAATAACTCAGCATGTGGCAGTGATAGAGA AAAGCATTGTGAACCACTTTTGATCCAATAAGATCTGAAGCTTCTGTTTTATATTTTACACCCCCGTTAC CTTGAAATGGAATATATGTATAATGTCTTTGTATGTATACATTTTTGAGAGAGTCTGACTCTGTCGCCCA GGTGGAGTGCAGTGGTGTCATCCCGGCTCACTGCAGCCTGGACCTCCTGGGCTCAAGGGATCCACCCACT TCTGCCTCCCAAGTAGCTGAGACCGCAGGCGCACCACCATGCCTGGCTAATTTTTTATATTTTGTAGAGA CGGGGTCTCACTATGTTCCCCAGGCTGGTCTCAAGCGCCTGAGCTCAAGCAGTCCTCCCACTTCAGCCTC CCAAAGTGCCGGGATTACAAGCATGAGCCACCAAGTCCAGCTATGTGCAATTTTTAAAAGCCAGCATAAT TAATACCCTAACTGGAATATAAAGGAGAAAATGTAAAAGTAGTTTATATTAATAATAAAATTACATGTAT TTCAGTATGTAAATATTGCTATGACTCCCCTAGTGAGATAGTTGTGTTTAAGTCTCTACTTAGAAATGCA GGTACACAGGTGTGTTACATATCAGGCACCCCAGGAAAGCACTGTACCATTCCCGATGAGATTTTCTGAA ATGGTGAACAATTCTTGGGAATGTTCTATGTGAAACTGTACAGTTGTCCCTCAATTTACAAGATATTTGT ACTGTATGTGAAAACCATGTAGAGGCTGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGC CAAAGCAGGAGTACTGCTTGAGCCTAAGGGTTCAAGACCAGCCTGGGCAACATAAAGAGGCTCTATCTCT TCAAAAAATTGGCTGGGCTTGGTGGCATGTGCCTGTGGTCCCAGTTACTTGGGGAGGCTGAGGAGGGGAG GATTGCTTGAGACCAGGAGGTCAGGAAAGACAGTTTGTGTTTATGTGGTAAAATATAGTTTGGCTTAGAT AATATGAACGGATAATTTTTACCCACACAAATGTCAGAATGTTCAAAAGTCACACAGGAAATGGGGCAGT TCATGTCAGATAGTCTCAAGCCAAGAAGGATGTCTGACTTTATGGATTCCTGCCCACCACATCTATTAGC ATTACCCTGTCACTGTAACCAGTAGCAGTGTCCACCACGATCACCCTAGGGGACAGTACTGTCCCTCTTT AAATTTCTGGCCTGGAGTCCCAGGACAGCCTTTAGGGCCTGAAGAAGGTGTGTAGGCAGAAGTATAGATA CAGCCTCTGACTGTAGAGACCAGTGTCAGCGGAAGGCTAAGGGCGTCTGTTTCATGTGACCTGCCGTTAT GCCCTCTGTGTACCTGGGTGTGAAGGGCTCAGGAAGGGTGCTGCAGCCTGGCCTGGGGGACCCCCCTAAT ATGCTCTTTTTTGCAGAAGCGGGCCCAGGATGCTGTGATCATCCTGGGGGGAGGAGGACTTCTCTTCGCC TCCTACCTGATGGCCACGGGAGATGAGCGTTTCTATGCTGAACACCTGATGCCGACTCTGCAGGGGCTGC TGGACCCGGAGTCAGCCCACAGACTGGCTGTTCGCTTCACCTCCCTGGGGCTCCTTCCACGGGCCAGATT TCAAGACTCTGACATGCTGGTAGTGCTCCCAGACACCCTATACATTAAATACAAAGGCGAAGGCTGCAGT CCCCTAAACTTCTCAGCTGGGACTGATCTTTTTGAAAACCAGAACCCCAAGTGAGCAGTGGGGATTTGGA ATTCAGTCTGAGCATTATTATTTTATGTCATGTAATTAGCAACGATGATTATCTATTACGTATATGGGAT TGTGTTAGGCGGTGTTCTTGTTTGATCCTCCCAGCTGCTCCATGAGCTGGATCCTGTTACCATCCCCAGC CATGGATCAGGAAACTGAGGAACAGATTAGCAACATAAAGGAACTCAAGTCACACAGCTAGGAGGTAGCA GGACCAGGATTCAAACCCACAGAGTCTGACGCTGGCTTCCCGCCCCTTGGCCACTGTCCTGCCTTGCTGA GGTCGTGGGTAGCTCAGTCTTCCCCTCAGCTAAATGGGGAAGCTGCCAGAGTCATTAAGCACTGGTGAGA GGCAGGAGCATCGTGTCCCAGCCTCACTCAGCCACGTGTTCAGCACACGGGCCCTCTCCATATGCTTGAA ATCTTTGGCCTAGAGTCCCAGGAAAGCCTCTAGGGCAGGAAGAGGGTGTGTAGGCAGAAGTGTAGATACA GCCTCTGACTGCAGAGGCCAGTGTCAGCGGAAGGCTAAGGGCCTCTGTTTCATGTGACCTTCCGGGCTTA GTGCAGCAAACCGAATAAAAGAGTCCCCATCCTCATGGAAGCTGCTTCCTCATGGAAGCCTTGGCAGTTT CCTTTCGAGAGGCTTCTTACCAAATGGGAGGACATCAGAATGATGAGTGTGAAAATGCAAACAAGAAGCC CTCAGAACTCTGGTGGGAAGGGTCACTGTTATAAATTAAAGGGGCCTTCACCGCATTTTCTCTTCCTACC TTAGACTCCTCTTCACTATCTGATTATATGGTGTTGAGCAGACGTGTCATTTCCCCTGACTGGCCATGCT CACACACTAACAGGCACTGTAGGCTCAGAAAGAGCACTCCGTTAAGGTGTCCTCACCTCAGACTGCTAGT TTGAGAGCCCTGGAACCAGTGTAAAATGGGAGTGAATAATGAGTGGGGTGCAGAGATGGGGTGAATTTAG AAGGAAGTGCGGGGTGCCTGAGGGTGCAAGCTGTGTCTGTATAAACACAGATGACAGAGACAGGCAAACC TGACCTCTGAGGTGTTGTCCTCAACACCTCTGCGTGGGCCCACACTTGCAGCAGCTCATTTAGAATGTGA CTCAGACTTTTTAACCGGTAACCAGGATTCTTGATTTCACAACTTTCCTGGTTTGGCTCTCCACCCTTCA CCTATGTCAGGCATGTTAGAATCCCCCGGGGGTGCACTTGGAATATTCAGATGCCCTGGCCTGGTGCCAG ACCAGTTTCACCGCCACATCTGAGAGCAGGACCTGAAAGCTGCCAGGGGCCTTTGTGGTGCAGCTGGAGC TGAGAACCACGGTCCTGGAGGAAGGCCCCTACACATCTTGCCTACCAGTCTCCTGAGGTGCTGTGAGCAT TCTCACCTTCATTTGTTGCTCTTCCTTCTTGGAGCATCTCTCTTAATCCCCTGCTTCCAGGATCCGACCG TGTTCACCCCGGGAGGCCTTTGCTAGTCTCCTGAAAGGTCGCTGGAGCCCATCAGTCAGTTCTGCCCAGC TGAACATCTTCCTTCCTCTGGTTCCCCGTGGGAGGCTGGGGGACGTGGCTGGGGCTTCTTGCCAGCCCGG ATGAGGAGGGACACAGCTGGAGCTGATGTTTATTAAGCTGATTAAAGGGTTTTGCTGCTTGACACGCCTT GGTTTCAGGGAAGCACTATCTAGGGCCTGACACCAGCGAGCTACTCCCTCCCACCAAGGCTAGTTGATAA GAAGGTATGAACCTTAACCACAATTGGAAAAGACAGTGCTCGTCTCCGCTTCAACCCACGGTGGAAACAC CATTTCTCCCCCCAGGCTTGCTAATAATAAAGCCCCGTGGTTTTCAAACTCTAGCTGGTGTCACAGTCCC CTGGAGAGCCAGCACTGTTAAAAATAGTTCCCCCAGTGCTCCATTCCACCCCCAAAGATTTTGACCTTGG GGGTGGGCCCTGGGATCTGAGGTTTCACAAGCTTCCCAGGTCATTCTGATGTAGCTGTGCCAGGAACCAT GCTTTGAGAAATACCGGGATAGCCTTAGCGTGCCTCTGACTTTGTCTTCCTCTTCCCAGGAAGTGAGAGT TCTGGGCCATAAATTCCGAAATCCAGTAGGAATTGCTGCAGGATTTGACAAGCATGGGGAAGCCGTGGAC GGACTTTATAAGATGGGCTTTGGTTTTGTTGAGATAGGAAGTGTGACTCCAAAACCTCAGGAAGGAAACC CTAGACCCAGAGTCTTCCGCCTCCCTGAGGACCAAGCTGTCATTAACAGGTAGGTGAGCGGCCCAGAGTT AACGGGGGATGCCCTCTTTCCAGCTGGGGGCGTTCAGAGATATAAGATCTGCCTCTGTTTTTTTTCTCTC ATACAATGTGGACATTCTTCTGTCATTTGGAATGTTCAGGAACCCTGTTCAGCATCTACTATGTGCCCCA GGCATCTATCTTGAAAAGCATGCTTTGTTACGTCCATTTAACAGTTGGGTAGATGGAGGCTCATAGAGCT AAATAACTCCGCTTCGGTCACGGAGATAATAAGCAGGAGAGCTTGGGCATGGCCTGGGCTTATTGGACTT GAGAGTTTGTGCTCTGTCCATGTTGTTTCTCCAATGCTCTTACTCGACACTGTCCAGGAGAAATGTAATG TGAGCCCCATATGTAATTTAAAGTACTCTAGTGACCACATTAACACAGTAAACAGAAATGAGTGAAGTTA ATACTTACTTAAAATTATAATTTATATTTAATGTTACAAGTATTTAAAAAAACGTATATTTAAAACACCA TAAAAAGTATTAATTCGCTGTTTTTACCTTCTTTTGCCTGTACCAAGTCTTCAAGAGCCAGTGTGCATTT TACTTCCAGCACCTCTCCCTTTGGACCAGCTGCATTCCCAGCAGCCAGTAGCCACATGCGGCCAGCAGGC TTGTATTGGCTAGCACAGCCCCAGCCTTTAGCAAACAGGGAAATGTAATATTCAACATGCACAGCTGCTC TTAGTAAGAGAAATCCTTCTAGACTGTATAAAGCCCTTCCCTTTGTCATCCCTGGGCAATTTTTACTACA GCAAACCCAAAAGGTGAAGAAGTGCTTACTTTTTGGTAAGAGGATTTTGAAGAGCCTCCTTGGGGAGATT TCGATGGGCATCTTTGGGGCCACTGGTGGCCTCCTGGGAGACGGACCTGTAGGACATTTACTTGGCCGTG CTTCCTGCTTTCTTGTGCTTGTTTCAGGGAAATTCTCCAGCATTAGAGATCAAGTTATTGATCTTTCTGC TGCATTGCAGGTGGGGATCAATATCTTCAGAATTGGCCAGGCAAAATATATTTGCTTAACATTCAGCTGC TACAGATAACTGCAGGTGCTGGGATGATGGTACTTGGTGAATCCTATAGGTGAGCAGGGGTGTGAGATCC TGCTCTGAGCCCTGTGTGTGCGGCCTCCTGGTTGTGTGGCATGTGGTAAGTGTGTAGTAAACACTTAATG AATGGGTGAAGTTATGAAGTCATCAGATATGTGTGCCAGTGTGTCTGTTATTATGGATGCTTTTGGCTCT AACAAAGTGGCTTAAACAACAGGCACATTTGATATTATTTTCTTCTCATAACAGGTGCAATGGGCAGGTC CAGGGTTGGTTGAGCACCAGGGCAGTGTTGAGACTCTGGTCCAACTTCTCTGGGCGTTTTCTTTTTGCTT GTCAGAGAGCGACCTCGGCTGCAAGTATTATGTTCTTACACGGACGCCCAAGAGCAGAAAGGAAAAAGGG CAGGGATGTTCTCAGAGGCTCCCAGTAGGTCTCACTTGTGTCTCAGTGTCTACACTTGGCATACACTTAC GCTTCCCTTGCCAGCAAGGCTGGGAAAGGAGTCATTAGCATTTTTACCCTGTATCAGGGCAGGTGGGTTT CACTGGCAAAGAGGAAGAGGAAGGGGACTGGCCACTAGGTCAAAACCCACAGTGGGGCTGGGGATACAGG GATGAAAGAGAGATGAGGCTCCTGCCTTCAGGGAGTGTCTAGTGACAGTGACAGAGGGATGAGAGAAGTA TGAGATGTTGCTCACCCTCAAGAAGATTGTAACCTAGGGACCTTAAGCATATATGTATGTATCTATCCCA AGCCAGGAGAAAGGTGGGGCCAAAGCTCTGTATGAAGGCCAGGGGGATGAGGGATCCTTTGCAGCTGCGA GCTCTGTGCAGGAGGAGAGGGAGCGTTTGCTCTGAGCTAGGAAGAGAGGTGATTTTCAGACAGAAAGCCT AGAGAGATGGAGTGGCTGCAGGGGCTTCAGGAGGCTGTTTGGGAGCCCAGGCAGAAGGTGGCAAGTGAGT GTGCAATTCTCAGAGAGTGGCTGGGTAAGGAGTGGGGATCCAGCAGGTCTGGGGCAGCTGCTGCTGAGTC TGGGCTGTTTCCAGTGCTAGCTGGCTGAGCATTTGCAAATTTTAATCTTTCCCTGGGTATTGGATGGTGT TCTGGCAAGTTCTCTAGGAGTCCCAGTGGTGTTTAGACCCTGGAAGTGTAAGAACTGACTGTGATTTTTT TTTTTCTCTTGTTTGAAAAAGTCCTAAGTGTATGGGAAGTGGCTATGGTGCCGTCTCACTCTGCCCCTCC CGTGTGCTTGTGCTCTGCAGGTATGGATTTAACAGTCACGGGCTTTCAGTGGTGGAACACAGGTTACGGG CCAGACAGCAGAAGCAGGCCAAGCTCACAGAAGGTAAAGTGGGGTTGTGTCAGTGGGCCTTTCTTATTTA TTAGGAGGAAACGTGGGAGAAATGCTGGGAACATTTCTAGTGAAATAAACATGATTGAGCAATAGCAAAA ACCACTGAGGACCTCAGGACACCTCTCCTAGAGCGATTTTCCTGGTCCCACACAGCTTCCAAGAGTTTAA CTGGATTTTGCAATTTAGCAAATACTCACTTTGCCTCTGCCTTGTTATGTAACCTGTTACCGTAACTAGG GAGGCCTGAAAGCAAGCGAAGCAAAGCGGCTGGGCAATGATCACACAGGCAATGAGGGCAGGAGCAGGAC TTGAATGTCATCCTCCCGTGGCCCACTCTGTCCTCCCTTTTTTGTCATCCATTGTGTAAATAATGTTCAT TAATTATAGAAGACTTAGTAAATACAGAGAAGCGTAAAGAAAGAATGTTCAAGAAACAGATACTCCTCCC TACTCAAGGCTAACTAATATTAGCATTTGGGAAAATATTCTTCATGAGTTGTTTTGGAAACTCATTTTTG GTTCGGGACAGTTCACACCTGTAATCTCAATACTTTGGGTGCCCAAGTTGGGAGGATCACTTGAACTCAG GAGTTTAAGACCAGCCTGGGCAACATGGTGAGATCCCATTTCTCTAAAAAAACCAAAAACAACATGCTTT TTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCCAGGCTAGAGTGCAGTGGCGGGATCTCGGC TCACTGCAAGCTCTGCTTCCCGCGTTCTCACTATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTTCA GGCACCCGCCGCCACACCCAGCTAATTTCTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTGTGTTAGC CAGGATGGTCTCGATTTCCTGACCTGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGC GTGAGCCACCGCGCCTGGCCACAACATGCATTTTTGAAGACGCCTCCGGCGATGCGGGTGTTCTCTGTGG CCTCTGCCTCACTTGCTCTCAGGATGCACTTAGTGGTCGCAGCCCTCTGTTGTCCTGACCCTAATGCCCC TGGGACCCTCTGGGATTGTGTGGGGTTGTGGCTCAGTAGCGACCATTTTCTTCTTTGGGTCCCTCTGAAA CTCCTTCCAGGATGTCTTAGTCTCAGATAGTCCTGGTAGCAGGATGAAGAAACCAATGGATATGGGATTC ATTTCAGGAAGTGAGGTGGAAAGGGCTGAGGCACTCAGCAGTGTCAGATTTGGGGAATAGGAAATTATCT TTTGGAAACCCCTGGGTTGGGTGGAACCAGACCCCGCTGTACTGCAGAGCCGCCCACCTGGGGAGCTTTG GAGGTCATCACAGGACTTGCATGGTTTGTGATGCTTGCCCGCCTTCGTGCTTGCTTTTTCTTCTCCTCGG TGTCTGCAGTGCAGTGTCCTGGCTTTATCTCCTGTTCTTCCTCACCCAGCCCTCCCTCCCTGTGGCCCTC CTGGTCTACGGAGTGAAGCGGAGCCTGCAGCAGTGCTCTGCACGGATGTGTCTGCCAGCAGCTTAGGGGC CTTCATGGCAGCTTGTTGTTAGCACCATGCCAAGGAACACGCGTTGACAAAAGCTTTGGTGCCCTCTGGG GACAGAGTAATCCAGCAATTTCTGTCTAACTCCCAAATCTTGTCAGTTTGGGCAGATGACTCCTAATCCG TTAGCTACATGAAAGTGATATTCTCCTTCAAGTCAGTTTACTTGTGAGGAAAAGAATTCAAGCTTACAGA TGATCTTGGCTTGATGGGTGCTAGACTGGGAAGCTTGGAGACCTTATGATAAACCTTTTGTCTAATTGGA TTCTTTGTTTCTTTTGAGACAGAGTCTCCCGCTATTGCCCAGGCAACAGTGGTGCAATCTCAGCTCACAG TAGCCTCCACCTCCCAGGTTCAAGCGATTCTCCTTTCTCAGCCTCCCAAGTAGCTGAGATTATAGGCGCC CACCACCATGCCTGACTAATTTTTATATTTTTAGTAGAGACAGGGTTTCACCGTGTTGGCCAGGCTGGTC TTGAACTCCTGACCTCAATTGATCCACCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCTG CTGCGCCCGGCTTCTAATTGGGTTCTGATCCCCTCCTCCAGTCCCCACCCTGGAAAGTAGCTACACTCAT CTCATTTGCTGATGATGCGAGAGTGTGATTGGGGTTGGGAAGGTGGTGAGCAGTACAATAGATGTTGTTT GATCCTCTCTGGCCTGACAACACATTTTGTGAGCTACTTGGTGTTCTAATTCTTCCCCCAACTCTCAGAT CAAAAGTACAGCCTGTACCATTGATGTACCACTCCCCGTGCAGATAAGATAGTAAACTTAGAAGAAGTCA AGTAGAGACAACCCGTTTCTTTTACACATAGTGTGTTTCTGAAAATGTATTTTTTCTGGAGGTCCAAAAT GCAAGTCCATTGATAGTCCTGTGGATTTTTAAGTAAGCTGACCTAATTGCTTACATGTAAACTGAGACCC TCTTGAGAGTAAAAAGGGGCAGGTGTTAACAATGATGCCCAGGCTAGGGGAGTAATCAGGTTGTCCAGGG AGCACCTAAGATACAGGGTACCCTCAGTTATTATATGAGGGAGAGTCCCTTTCCTCAGAGAACTAAAATT ATAAGTTAGAAAACAATTACACCTCTACATTTTAGGCATGATAATTGAAAACATTTGGCCGGGCATGGTG GCTCACGCCTGTAATCCTAACACTCTGGAAGGCCAAGGCAAGCGGATCATTTGAGGTCAGGGGTTTGAGA CCAGCCTGGCCAACATGGTGAAACCCCTTCTCTACTAAAAATACAAAAATTAGGCCGGTTGCAGTGGCTC ACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCATGAGGTCTGGAGATGGAGACCATCC TGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCACATGCGTG TAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATTGCTTGAATTCAGGGGACGGAGGTTGCAGTGAGC CAAGATTGTGCCACCACATTCCAGCCTGGGCAACAGTGAGACTCCATCTCAAAAAAAAAAACAAAAAACA TTTTCCAGTATATATATATGTGTATATGTATATGTGTATATATATATATATATATATATATGTGTATATA TATATATATTTTTTTTTTTTTTCTTTTTTTTGAGACAGAGTCTTGCTCTGCTCCTTAGGCTGGAGTGCAG TGGCGCGATCACGGTTCATTGGAGCCTCAATCCTACTTCAGCCTCCCGAGCAGCTAGGACTACAGGTGTG CACCACTGCTCCCGGCTGAGTTTTCAATTATAGAGATAGGGTTTCACCATGTTGCCCAGACTGGTCTTGA ATTCCTGGGCTCAAGCAATCCTCTGCCCTTGACCACCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGC ACCTGGCCTGTTTTTCAGTATTTTATACATGTTCTTTCATTTTGTTTTTTCTTCGCAACTGTACATCCAG TCAACCGAGCCAAGGCCAACAAGCATTCCTTGAGGTGAGAGTTGCGGGCCTGATGTGCCTACTGAGTTCT CTCTGTTCTCAGTTTTATTCAATTTATGAGGCCCATCTTTTGCCCCACAAGTATTTGCAGTAATTTGTCC ATTTTCCATGAAAATTTTAAAAATAAAAAGGGCAAAATGCAGCAAAACATCCTCGTAGCTGCCCAGACTT TGCTAGACAAAGCCAGTGAGTGGTTTTGGTCAGCAGGCGGGCCCAGGCCGCAGTTGAGCACCTGTCAGCC GGTGTCGGGCAGGTCAGGTTTGGAGGGAAGGCCTGCGCGGCTGTCCACAGGTGGTTTGGTCAAGGGCAGC CTCAGAAGGTGGCACAGGAAAGGGTGTGCGGGGTGCAGGCCTGACCAGCGATGTTTGCAGATGGACTGCC TCTGGGGGTCAACTTGGGGAAGAACAAGACCTCAGTGGACGCCGCGGAGGACTACGCAGAAGGGGTGCGC GTACTGGGCCCCCTGGCCGACTACCTGGTGGTGAATGTGTCCAGCCCCAACACTGCCGGGCTGCGGAGCC TTCAGGGAAAGGCCGAGCTGCGCCGCCTGCTGACCAAGGTGGGCAGCTGCACCCCTCTCCAGGCCCTGTC CCACCAGCCTGTCCCACCTGCTCCCCTTCATTCTCCAGGGCGAACCTTCAGCATCACCCTCAGAAGCTGT CCTTAGCACCTAGACCAGTAGGACCCCTGGCTATACCTTCCCAGAGTCCCCTCTGATCCCCTCTCATGAC ACTGATTATATGCGACGGTGACAAATTATCTGTCCCTGCTGCTATAAATCACGGGGTCTGTAAGAGCAGA CACCACGTCTCTCTCATTTGTCACTCTGACCCTAGCGCCCAGAGCTCTGAGTGAACTGAAGGACTTCATC ACCCAGTACATGTGGTAATATTTCCTGGTTATCTTTTAGGAATAAAAGTCTAAAAAACGTTGGACACCGT GGCTCATGCCTGTAATACCAGCACTATGGGAGGCCAAGGCAGGTGGATCACTTATAACCCAGGAATTTGA GACCAGCCTGGGCAAAAGAGCAAGACCCTGTCTCTACAAAAATTTAAAAATTAGCCAGGCACAGTGGCTC AAGCCTATAGCCCCAGCTACTTGGAGGCCGAGGCAGGCAGATCACTTGAGCTCAGGAGCTGACCAGCCTG GGCAACTTGGCAAAACCCCATCTTACAAGAAATACAGAAATTAGCTGGGCATGGTGGTGCACACCTGTAG TCCCTGATACTCTGGAGGCTGAAGTGGAAGGATCGCCTGAGCCCAGGGAGGTGCAGGCTACAGTGAGCCG TGATCATGCTACTACACTCCAGTGTGGGTGACAGAGTGCGACCTTGTCTCAAAAAAAAAAAAAAAAAAAG AAAAGAAAAGTCTAAAACACCCTTGAGCTATTAGCCAATGTCCACGGGATCCCTTGGCCTAAAAGAATGG AATCGGATCCATCTCGACTGTACTCCTCACGTCTGAGGGCTGGCTTTCCTGAAAAGAAATTGTTTCTGCT TTAGTTTGATCGCTATTGTGGAAACCCACTGACCTGCAGCGTAGGTCACAGCTGCACTGCAGGGCTGTGG TCTGCGGGGTCCCCAGCTCTGGCCGTGTGTCGCCCTAGGTGCTGCAGGAGAGGGATGGCTTGCGGAGAGT GCACAGGCCGGCAGTCCTGGTGAAGATCGCTCCTGACCTCACCAGCCAGGATAAGGAGGACATTGCCAGT GTGGTCAAAGAGGTTTGAGTCGGGGCCTGGGCCCAGGGTGTGCCTCCCATGGTCTGCAGAGGCCGTTTGG CCAGCTGGGCTAGCCCAGAATGGCGTTCTTTGTGATTTCCTCTCCTTGGTATTCAAGGCTGGTTTGGTGT GTGTCATGGTGTAACTCACCCTGTGGTCAAAAGCGAATGTTGGAATAAGTGCTTGAAGGAGTTTTTCTAA TGCCTCTTCCTCTCTTTTGTCAACTGCATCCAGCAAGTTTAAGGCTTGAGCTTGGCTCCTTGGCCAGTCT TGACTGGGACTGAAAATTCTTTCTCTCACTCCTCTCTCCAGCCTGTCTGGACAGCGGGTCTCTGTGGCAT AGGAGAGTAGTGGAAACAGACTGAGCCCGGCCATCGTGGGTTCAAATCCTGGTTCCACCACTTACTACCT GGGGGCCTCAGACAAGACACTGTAATTGGGTTGTTGTAAGGACTGGACCCTGTCCTAGGGGAATGTTGTG GGTGGTCAGCGTGTGATGGCTGCTGTCGTCATGTTATGGCTCATTCTAAAACTTGTTGAGGAAAAGATGA GTAGTGAGGTCTGGTGTAGCTCTTGCTTTGGGGGCTGTAGGTGTGGGTACCTGGCCCGGCTGCTGCCTTC GACCTCCAGAGAAGCGCCTCTGGGTCCTTCGGTGCTATGACTCATGGCTTTTTCTCTATCTCGCACTGCA GTTGGGCATCGATGGGCTGATTGTTACGAACACCACCGTGAGTCGCCCTGCGGGCCTCCAGGGTGCCCTG CGCTCTGAAACAGGAGGGCTGAGTGGGAAGCCCCTCCGGGATTTATCAACTCAAACCATTCGGGAGATGT ATGCACTCACCCAAGGCAAGGTTTCCCGTGTTTGTGTCTTCAGATCTGCGTGTGGCTTGGGCTCCTGGGT CGTGATGGGAATCATCATTCCCTAATCTGTCTTGATTGTGGGGGACTCTGGGGCTGAAGCCACATCCTTC TTTATGGTGTCGCCATGTGCTTCTCTGTAGGCCGAGTTCCCATAATTGGGGTTGGTGGTGTGAGCAGCGG GCAGGACGCGCTGGAGAAGATCCGGGCAGGGGCCTCCCTGGTGCAGCTGTACACGGCCCTCACCTTCTGG GGGCCACCCGTTGTGGGCAAAGTCAAGCGGGAACTGGAGGCCCTTCTGAAGTGAGTGAGGTCATGTGTGG CTTGAAACAGAAGTTAGGCAGAGGTTCATTTAGATCACTCAAGTCAACGAGATACTGTTGATCTGTTTCT TATTCATTCAAAAAGGAGTTGAGGGGTACACTCTGAAGGGGAGAGAAATTCTGGGTTACTCTTTTGATGA AGGACAAACAATGCCAAGGAGAACTGAGGATTAACCTCCAAGGCAATGGTGTTTCTAAGGTGGAGTTGTC CATTTGCTCAAGGGAGGGGAGCCTGAGGAATCCCATCAGCATTCCCATTAATTAAGCAACACTGGTTCAA TGTTGGGAGCTGTCAATACTTAAAAGCAATTTCCTTCCTGCTCTGTTCCTACCTGGGTAGAAATATCCCT AGGTCTCTGGGTGAAGAGTGTAGAGGAAACCAGATGTGCCTGGGCCGGGATGATGCGTTTCTGGGTGAAC GTGGGCTTCCTGTAAGAGCAGGGCCTGTTCTCCACTGTTTGCTGAAATTGCTTTGTTTGCTCTTTTTCCA GAGAGCAGGGCTTTGGCGGAGTCACAGATGCCATTGGAGCAGATCATCGGAGGTGAGGACAGCGTCTGAC GGGAAGCCTGATCTGGAACCTTCCCAAGGACTCAGGCAAGCCTTTGTGGCTGGATCATGAGAGGAGGGAC TCCATCTTGAGCCATGTCCCCCAGCCATGGCATGGCTGCACTGTAAACGCCAATCGGGGGGTCACCAGGA TCAACCGCAGGCTTTCTTCAGTCCCTTGGTCAGACCATAAACTGCATTTTTGATTCTTTGTGGATTCAAA CCCTAGGATCCATCAGTCTTGCAAGGACATTGAATATTAGGAGGAAAAAGTCATGGAAAAAATAAAGCCA TTTAGAACCTGGGTTTCAACGCTAGCCCTTTCTGGTTTGCCATAGGCCCTGCCAAGATACTGCAGGTCCA TCCAGGCCTCTGCTATCTGCATCTGCAGTGGGCTTCCCAGGAACTTGACTGTCTTTCATTTGATCTTTAT TTTTGTTTATTTAATATTTTAAACTTTATTTTAAAAATATTTCAAACATAAGGGCGGGGTGTGGTGGCTC ATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACCTGAGGCCAGGAGTTGGAGACCAG CCAGGCCACCATGGTGAAACCCTGTCTCTACCAAAAATACAAAAAATTAGCCAGATATTGTGGCAGGCAC TTTTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTG AGCCAAGATTGCACCAGTGCACTCCAGCTTGGGCGACAGATCAAGACTCTGTCACACACAAAACAAACAA ACAAATTTTCCCGTTTCTCTCTGTCCCTTTCTCTATAACATGGATAAAATATTCACGTCTTATGTATTTA TTATTGCTGAGTCATTGGTGCCTTATTCTTCAGTGTTTCAGTCTGTATCTCCTAAGCATCCTGATGTTAG TTTTTTGACTATAAAATTGACCTGCATTCTTTACTAGCAATTCAAACGGTACAGCACTCTTGAAGTGTAA ACATTCCTGTTCCTCCTCACCCCACTCTGCAGACATGCCTTTCTGTCTGTCCTCCCAGACTTTTCCCCTG CATAAAGATGTTCATTTTGTACATACACTCAGACATACATGTGGCTGTATTTTTTGTATACCGATTTCTG GATGGAATGCACACTGTTATCTGTTTAGTTACTTTATGTTTTCATACAAATGACATCATCCCACAAATAG AATTCTGCCATTTA code code <span style="background-color: #ffffff; font-family: monospace,serif;">>XP_005255884.1 dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1 [Homo sapiens] MATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFD KHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQA KLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQ ERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPL RDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLK EQGFGGVTDAIGADHRR code code <span style="background-color: #ffffff; font-family: monospace,serif;">>XP_016878479.1 dihydroorotate dehydrogenase (quinone), mitochondrial isoform X2 [Homo sapiens] MGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGV NLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRP AVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREM YALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI GADHRR code code <span style="background-color: #ffffff; font-family: monospace,serif;">>XP_005255886.1 dihydroorotate dehydrogenase (quinone), mitochondrial isoform X3 [Homo sapiens] MWYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVS SPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTN TTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQ LYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR code
 * Trypanosama brucei brucei Protein Sequence ([]):**
 * <span style="font-family: &#39;Times New Roman&#39;,Times,serif;">dihydrooroate oxidase Gene Sequence (Hono Sapiens): **
 * <span style="font-family: &#39;Times New Roman&#39;,Times,serif;">dihydrooroate oxidase Protein Sequence ([]): **