Journal+Club+Fall11

Every other week we will have a Journal Club wherein we discuss a paper in small group formats. There will be a Question sheet that each group will work on collectively - but each person will turn theirs in for a grade.
 * Journal Club Discussions**

You are required to PRINT OUT the __paper__ and BRING it to class with you! __(bringing it on your laptop or phone does not count!)__
 * you are welcome to print these papers in the Painter Lab (please do 2 pages per sheet to converse paper)
 * Also, while you are at it - be sure to ask a friend if they need a copy printed too

Journal Club Papers


 * 12th Week:** 11/14 none

Paper: Link to PDF
 * 13th Week:** Nov 22nd - In Class exercise (no assigned paper)


 * 14th Week**: none


 * 1st Week**: none
 * 2nd Week**: none

Paper:
 * 3rd Week**: Sept 14th
 * 1) Park, H.; Kim, Y. J.; Hahn, J. S., A novel class of Hsp90 inhibitors isolated by structure-based virtual screening. //Bioorganic & Medicinal Chemistry Letters// **2007,** //17// (22), 6345-6349.
 * Park Hsp90 paper
 * 1) Alanis, A. J., Resistance to antibiotics: are we in the post-antibiotic era? //Arch Med Res// **2005,** //36// (6), 697-705.
 * Alanis paper


 * 4th Week**: none

Paper: Tomlinson, S.; Malmstrom, R.; Watowich, S., New approaches to structure-based discovery of dengue protease inhibitors. //Infect Disord Drug Targets// **2009,** //9// (3), 327-43.
 * 5th Week**: Sept 27th



Paper: Kovac, A.; Konc, J.; Vehar, B.; Bostock, J.; Chopra, I.; Janezic, D.; Gobec, S., Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening. //J Med Chem// **2008,** //51// (23), 7442-8.
 * 7th Week**: Oct 11th


 * Study Q's:** answer these and bring paper copy to class [[file:vdsstream/JournalClubQuestions10111_DalaDalaLigase_StudyQs.doc|JournalClubQuestions10111_DalaDalaLigase_StudyQs.doc]]




 * 8th Week**: none

Paper: Ruda, G.; Campbell, G.; Alibu, V.; Barrett, M.; Brenk, R.; Gilbert, I., Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. //Bioorg Med Chem// **2010,** //18// (14), 5056-62.
 * 9th Week:** Oct 25th


 * Study Qs:**
 * [[file:vdsstream/JournalClubQuestions102511_6phosphogluconateDehydrogenase_StudyQs.doc|JournalClubQuestions102511_6phosphogluconateDehydrogenase_StudyQs.doc]]**




 * 10th Week**: none

Paper: A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through Computational Screening against the Neuraminidase. Jianghong An, Davy C. W. Lee, Anna H.Y. Law, Cindy L.H. Yang, Leo L.M. Poon, Allan S.Y. Lau, and Steven J.M. Jones //J. Med. Chem.// **2009,** //52,// 2667–2672 Study Q's:
 * 11th Week**: Nov 8th - Journal Club #5