Target+-+glutathione+reductase

Brugia malayi is a nematode that is known for causing lymphatic filariasis (elephantiasis). It is common in South and South East Asia, especially abundant in the tropical regions. B. mayali are spread through infections, unsanitation, and even mosquito bites that transfer the parasites. http://www.tdrtargets.org/targets/view?gene_id=240339 http://www.ncbi.nlm.nih.gov/pubmed/7032915 Bm1_04825 has essentiality data Gene/Ortholog: mtu2902 (OG4_10249); Phenotype: essential; Source study: nmpdr Gene/Ortholog: eco3379 (OG4_10249); Phenotype: non-essential; Source study: blattner Gene/Ortholog: eco3379 (OG4_10249); Phenotype: essential; Source study: gerdes Gene/Ortholog: eco3379 (OG4_10249); Phenotype: non-essential; Source study: keio Gene/Ortholog: eco3379 (OG4_10249); Phenotype: non-essential; Source study: shigen Gene/Ortholog: Tb927.10.10390 (OG4_10249); Phenotype: no significant loss or gain of fitness in bloodstream forms (3 days); Source study: alsford Gene/Ortholog: Tb927.10.10390 (OG4_10249); Phenotype: significant loss of fitness in bloodstream forms (6 days); Source study: alsford Gene/Ortholog: Tb927.10.10390 (OG4_10249); Phenotype: no significant loss or gain of fitness in procyclic forms; Source study: alsford Gene/Ortholog: Tb927.10.10390 (OG4_10249); Phenotype: significant loss of fitness in differentiation of procyclic to bloodstream forms; Source study: alsford http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.8.1.7 Figure 1: Reaction mechanism of glutathione reductase No enzyme assay available -- PDB # 3GRS
 * *Target (protein/gene name): **Brugia malayi, glutathione reductase, putative
 * *NCBI Gene # or RefSeq#: ** 240339
 * *Protein ID (NP or XP #) or Wolbachia#: **Bm1_04825
 * *Organism (including strain): **Brugia malayi
 * *Background/ Disease Information (sort of like the Intro to your Mini Research Write up): **
 * Link to TDR Targets page (if present): **
 * Link to Gene Database page (NCBI, EuPath databases -e.g. TryTryp, PlasmoDB, etc - or PATRIC, etc.) **
 * Essentiality of this protein: **
 * *EC#: ** 1.8.1.7
 * Link to BRENDA EC# page: **
 * Enzyme Assay information (spectrophotometric, coupled assay ?, reagents): **
 * Structure Available (PDB or Homology model) **
 * Expression Information (has it been expressed in bacterial cells): ** Yes
 * Purification Method : ** Affinity chromatography
 * *length of your protein in Amino Acids ** 480 amino acids
 * Molecular Weight of your protein in kiloDaltons using the [|Expasy ProtParam] website ** 50271 Da