TargetSummer17+-+calpain-like+cysteine+peptidase,+putative+(Trypanosoma+cruzi)

T. cruzi is a parasitic protozoan that bores tissue in other organisms and feeds on their blood and lymph, causing Chagas disease. The parasite is transmitted through insect vectors, such as bites, stings, or feces. Common symptoms of Chagas disease are fever, fatigue, headaches, and swollen glands.
 * Disease/Relevance:**


 * Location: **

In the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins.

Belongs to peptidase family C1

**Type of Enzyme:** Phosphatase **Brenda E.C.:** 3.1.3.16 **Structure:** 2 models on ModBase
 * Activity from Brenda: **None
 * Druggability: ** 0.6
 * Assay: ** Been done
 * TDR Targets Link: **

http://tdrtargets.org/targets/view?gene_id=39227
 * Inhibitors: **None


 * <span style="background-color: #ffffff; font-family: arial,sans,sans-serif;">Essentiality: **

<span style="background-color: #ffffff; font-family: arial,sans,sans-serif;">Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: no significant loss or gain of fitness in bloodstream forms (3 days); Source study: alsford

<span style="background-color: #ffffff; font-family: arial,sans,sans-serif;">Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in bloodstream forms (6 days); Source study: alsford

<span style="background-color: #ffffff; font-family: arial,sans,sans-serif;">Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in procyclic forms; Source study: alsford

<span style="background-color: #ffffff; font-family: arial,sans,sans-serif;">Gene/Ortholog: Tb927.10.6460 (OG4_10634); Phenotype: significant loss of fitness in differentiation of procyclic to bloodstream forms; Source study: alsford