Picking+Targets

Choosing a target to study in VDS is a tricky endeavor. There are several guidelines and constraints that we must adhere to. Here are a few of them.

Find ones that are in neglected diseases (i.e. less commonly studied)  Choose some disease organisms on the NIAID target list of Category A.B.C pathogens.  [] Also look at [|J Craig Venter site]
 * Picking Targets**

 Can choose any target if we know the DNA sequence since we can do Overlap PCR  Has an Xray crystal structure available:
 * PDB (Protein Data Bank)
 * PSI (Protein Structure Initiative)
 * SGC (Structural Genomics Consortium)
 * CSGID (Center for Structural Genomics of Infectious Diseases)

 But that have easy/cheap enzyme assays – phosphatases, carbonic anhydrases Phosphatases Carbonic anhydrases

The trick is ideally we want it to have a crystal structure, and we want it to have been shown to be expressible by someone else.