Phosphotyrosine+Protein+Phosphate+(Mycobacterium+tuberculosis)

__** PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB **__

Phosphotyrosine Protein Phosphatase PTPB
 * Target: **

886842 YP_001281440
 * NCBI Gene #: **
 * Protein ID: **

Mycobacterium tuberculosis H37Ra
 * Organism and Strain: **

B-III-A. Risk Group 3 (RG3) Mycobacterium tuberculosis is a species of pathogenic bacteria that is responsible for most cases of Tuberculosis. Tuberculosis is a serious infection that mainly attacks the lungs and is spread through respiratory fluid in the air, mostly from the coughing and sneezing of infected individuals. The disease stays latent in 90% of individuals who contract tuberculosis, but if the infection becomes active, will kill approximately 50% of individuals who do not seek treatment. Symptoms include a chronic cough, blood in mucus, fever, night sweats, and weight loss. The treatment of Tuberculosis is difficult and requires a strict regimen of antibiotics over a long period of time, however, there has been an increasing resistance to antibiotics amongst mutating strains of the infection.
 * Etiologic Risk Group: **
 * Background/Disease Information: **

Single Protein
 * Complex of proteins: **

A likely candidate
 * Druggable Target: **

3.1.3.48
 * EC#: **

http://www.brenda-enzymes.org/php/result_flat.php4?ecno=3.1.3.48
 * Link to BRENDA EC# page: **



http://www.jbc.org/content/272/2/843.short http://www.sciencedirect.com/science/article/pii/S1046202304001653
 * Enzyme Assay information: **

0.5 mg/ml in 50 mM HEPES, $467.50, Sigma-Aldrich
 * Cost and quantity of substrate reagents and supplier: **

PDB #: 1YWF
 * Structure Availability: **

PO4
 * Current Inhibitors: **

Expressed in escherichia coli bl21
 * Expression Information: **

Chromatography
 * Purification Method: **


 * Image of protein: **

MGSSHHHHHHSSGLVPRGSHMAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQ RALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVV TFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
 * Amino Acid Sequence: **

296
 * Length of your protein in Amino Acids: **

32317.1
 * Molecular Weight of your protein in kiloDaltons: **

1440
 * Molar Extinction coefficient of your protein at 280 nm wavelength: **


 * TMpred graph Image: **