Glycerol-3-Phosphate+Dehydrogenase+(Leishmania+Mexicana)


 * Target Protein:** GLYCEROL-3-PHOSPHATE DEHYDROGENASE
 * E.C. Number:** 1.1.1.8
 * Gene #:** 13450683

 **Gene symbol:** LMXM_28_3010  **Genomic Sequence:** NC_018332.1

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 * PDB ID:** 1EVZ
 * Protein ID:** Q4Q7J1
 * Organism:** //Leishmania Mexicana//
 * Etiological Risk Group:** Leishmania
 * Disease:** When a sandfly of the region of the tropics, subtropics, and southern Europe lands on the victim and releases the early form of the protozoan parasite as the promastigote and allows the the parasite to grow until the cell enters phagocytes and then continues the cycle. the infection manifests itself as a c utaneous form of leishmaniasis and skin abrasions.
 * Homology: ** Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania
 * Essentiality:** This plays a role in the life cycle of trypanosomes, which are what manifest this infection by going through the life cycle. By halting the promastigote stage of the life cycle the infection could halt growth before the infections spreads throughout the skin.
 * Druggable Target:** GDPH strands of this protein utilize NAD to catalyze various processes within the protein complex, such as interference with the blood stream in order to prevent against sleeping sickness.
 * Assayable Enzyme Target:**
 * Protein Image:**
 * Pairwise Alignment:**
 * Inhibitors:** n/a
 * Expression:** via E.Coli
 * Links:**

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http://www.uniprot.org/proteomes/UP000007259 https://www.ncbi.nlm.nih.gov/gene/13450683 code >NC_018332.1:c1127077-1124438 Leishmania mexicana MHOM/GT/2001/U1103 complete genome, chromosome 28 ATGCCTCCACCATCCCGTCTGGATGCTGTCTGCGATACCGCGACGACTGCTACCACCAACTTGGAAGATC TGCAGGAGCTGTGTAGGCGAGTGCAGCTGCTTAGAAAGGGTGTGAATGGCATCTTCAATAGGAAAATTCC CGCTTTGGAGTCCTCAATAGAGCAGTTCCATGAGACTCATTTGCATCACCTTTTGGCAACAAAGGATGAT TTTACGAAGGATTCACCGGTACACTCTATCGGTTTGCTTCTCAGCTCGATCGACGCATTGTTTTTGAGAG CAGAGAATTCTTCTCAAAAGAGGTGGACAGCTGCGCGCCGGAGTTCTGCTGCGGAGTCCTCGTCGACTAC AACCTTTGCTGTTGGATATTCGCCTGAAACTATGGTCCCCGACTCCGATCTGGTCCACTATGCAGAGCCC AATAAAGCAGAAATCAGACCTTGTGATAGCGTTCCTAATTTCCAACCACCTGAGAGACGAACTGTGACGC GCTCGGCCGGTGCTGGTGCCGCCGAGAAGCCTGCCGCTGCGCCGGAGAGCAAGCCCGCCGCCGGAGGGTT TGGGCAGGCCCCGTCGACAGCCTTCGCTAAGGCCCCTCCAGCCTCAAGCGCCTTCGGCCAGACACCACTG GCCGGAGCTGCGGCAGAGAGCAAGCCTGCCACTGGTGGATTCGCCTTTGGCGCCGGTGCTGGTGCCGCCG AGAAGCCTGCCGCTGCGCCGGAGAGCAAGCCCGCCGCCGGAGGGTTTGGGCAGGCCCCGTCAACTGCCTT CGCTAAGGCCCCTCCAGCCTCAAGCGCCTTCGGCCAGACACCACTGGCCGGAGCTGCGGCAGAGAGCAAG CCTGCCACTGGTGGATTCGCCTTTGGCGCCGGTGCTGGTGCCGCCGAGAAGCCTGCCGCTGCGCCGGAGA GCAAGCCCGCCGCCGGAGGGTTTGGGCAGGCCCCGTCGACTGCCTTCGCTAAGGCCCCTCCAGCCTCAAG CGCCTTCGGCCAGACACCACTGGCCGGAGCTGCGGCAGAGAGCAAGCCTGCCACTGGTGGATTCGCCTTT GGCGCCGGTGCTGGTGCCGCCGAGAAGCCTGCCGCTGCGCCGGAGAGCAAGCCCGCCGCCGGAGGGTTTG GGCAGGCCCCGTCAACTGCCTTCGCTAAGGCCCCTCCAGCCTCAAGCGCCTTCGGCCAGACACCACTGGC CGGAGCTGCGCCGCCCGCCGCCGGAGGGTTTGGGCAGGCCCCGTCGACTGCCTTCGCTAAGGCCCCTCCA GCCTCAAGTGCCTTCGGCCAGACACCACTGGCCGGAGCTGCGGCAGAGAGCAAGCCTGCCACTGGTGGAT TCGCCTTTGGCGCCGGTGCTGGTGCCGCCGAGAAGCCTGCCGCTGCGCCGGAGAGCAAGCCCGCCGCCGG AGGGTTTGGGCAGGCCCCGTCAACTGCCTTCGCTAAGGCCCCTCCAGCCTCAAGCGCCTTCGGCCAGACA CCACTGGCCGGAGCTGCGGCAGAGAGCAAGCCTGCCACTGGTGGATTCGCCTTTGGCGCCGGTGCTGGTG CCGCCGAGAAGCCTGCCGCTGCGCCGGAGAGCAAGCCCGCCGCCGGAGGGTTTGGGCAGGCCCCGTCGAC AGCCTTCGCTAAGGCCCCTCCAGCCTCAAGCGCCTTCGGCCAGACACCACTGGCCGGAGCTGCGGCAGAG AGCAAGCCTGCCACTGGTGGATTCGCCTTTGGCGCCGGTGCTGGTGCCGCCGAGAAGCCTGCCGCTGCGC CGGAGAGCAAGCCCGCCGCCGGAGGGTTTGGGCAGGCCCCGTCAACTGCCTTCGCTAAGGCCCCTCCAGC CTCAAGCGCCTTCGGCCAGACACCACTGGCCGGAGCTGCGGCAGAGAGCAAGCCTGCCACTGGTGGATTC GCCTTTGGCGCCGGTGCTGGTGCCGCCGAGAAGCCTGCCGCTGCGCCGGAGAGCAAGCCCGCCGCCGGAG GGTTTGGGCAGGCCCCGTCGACAGCCTTCGCTAAGGCCCCTCCAGCCTCAAGCGCCTTCGGCCAGACACC ACTGGCCGGAGCTGCGGCAGAGAGCAAGCCTGCCACTGGTGGATTCGCCTTTGGCGCCGGTGCTGGTGCC GCCGAGAAGCCTGCCGCTGCGCCGGAGAGCAAGCCCGCCGCCGGAGGGTTTGGGCAGGCCCCGTCAACTG CCTTCGCTAAGGCCCCTCCAGCCTCAAGCGCCTTCGGCCAGACACCACTGGCCGGAGCTGCGCCGCCCGC CGCCGGAGGGTTTGGGCAGGCCCCGTCGACTGCCTTCGCTAAGGCCCCTCCAGCCTCAAGTGCCTTCGGC CAGACACCACTGGCCGGAGCTGCGCCGCCCGCCGCCGGAGGGTTTGGGCAAGCCCCGTCGAGCTCCTTTG GGAAGGCAGTGTGTGGGGTGGGAGCAGGCAGCGCGTTCGGCATCGGCGGCGGGTTCGGATCTGCTGCCAC CAGCGCGAGCTTTGTCTCTGCGTCGACAGCAGGGTTCGGGCCCGCAAGCGCATTTACGAGTGCGTTTGGT GGCGCTCCTCAAGGCGGTGGCTTTGCGAGCGTGCCAAAGAGCGCCTTTTGTGGCGGAGGCAACACAAACA GTGCGTTTGGCGCATCGTCCTTCAGTTCACTGGCTGCAAACTTCCAGTAA code >1EVZ:A|PDBID|CHAIN|SEQUENCE
 * Gene** **availability:**
 * CDS Gene Sequence:**
 * Protein Sequence:**

MSTKQHSAKDELLYLNKAVVFGSGAFGTALAMVLSKKCREVCVWHMNEEEVRLVNEKRENVLFLKGVQLASNITFTSDVE

KAYNGAEIILFVIPTQFLRGFFEKSGGNLIAYAKEKQVPVLVCTKGIERSTLKFPAEIIGEFLPSPLLSVLAGPSFAIEV

ATGVFTCVSIASADINVARRLQRIMSTGDRSFVCWATTDTVGCEVASAVKNVLAIGSGVANGLGMGLNARAALIMRGLLE

IRDLTAALGGDGSAVFGLAGLGDLQLTCSSELSRNFTVGKKLGKGLPIEEIQRTSKAVAEGVATADPLMRLAKQLKVKMP

LCHQIYEIVYKKKNPRDALADLLSCGLQDEGLPPLFKRSASTPSKL