Journal+Club+Summer


 * Journal Club Presentations/Discussions**


 * Guidelines:**
 * prepare a 10 minute powerpoint slide show
 * Start out with a title slide that has the Journal Article name and Authors on it
 * Create an introduction that provides a broad perspective for the specific work being presented. For example, if you are presenting a paper on a new protein, you should provide some background on the protein family and what it does. Don't assume that everyone in your audience knows the background. You can use your own content if you like - along with that given by the authors.
 * Instead of simply describing the methods used, look at the methods critically, with an eye for anything interesting or unusual. Point out anything that might be generally useful. For example, did the authors use any techniques that we are currently using in our lab?
 * __Include graphs and figures from the paper__. You can also make your own cartoons and schematic diagrams or show relevant pictures to get across the point.
 * Make an effort to explain what is going on in the figures (you can leave out some if they do not contribute to a 10 minute presentation)
 * Be sure to actually show the images and figures from the paper when talking about them (include some type of caption)
 *  Do the results suggest any additional experiments that would be the next step?


 * Feel free to interject your own viewpoint of the research (is it valuable, did they do anything you liked or disliked?)
 *  Clearly explain the significance of the results. Results by themselves are dull, unless they have significance. The significance may not be obvious to the audience, so point it out specifically.
 * What is the most significant contribution of the specific work to the field in general?
 *  Try to appear truly interested (even excited!) about the work you are presenting. Enthusiasm is contagious, and keeps your audience interested. Can you think of anything to make your presentation unique? An unusual prop or visual aid? Make your presentation "professional". That means, stand up in front, look directly at your audience, and don't "read" your slides.
 *  Go through your talk at least once as a practice run

Upload your presentation __before__ class to the **GroupMeetingSlides/Journal Club** folder on **Google Docs**

1st Week: none 2nd Week: Justin & Marshall 3rd Week: J.C. & Joey 4th Week: Christina & Sadhana 5th Week: Krishna 6th Week: Jeanette, Larry 7th Week: Hong, Indra 8th Week: Joshua 9th Week: none
 * Presentation Order:**

7th Paper: July 26th - **Joshua** Tomlinson, S.; Malmstrom, R.; Watowich, S., New approaches to structure-based discovery of dengue protease inhibitors. //Infect Disord Drug Targets// **2009,** //9// (3), 327-43. [|TomlinsonWatowichDengueVirusInfectiousDisordersDrugTargets2009.pdf]

6th Papers: July 19th - Hirayama, K.; Aoki, S.; Nishikawa, K.; Matsumoto, T.; Wada, K., Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. **Bioorg Med Chem** 2007, 15 (21),  6810-8. [|VDS_UBL3_bioorgmedchem2007.pdf]
 * Indra**


 * Hong**

Sacchettini, J.; Rubin, E.; Freundlich, J., Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. //Nat Rev Microbiol// **2008**, 6 (1), 41-52. [|SacchettiniTuberculosis_DrugsVsBugsNatRevMicrobiol2008.pdf]

5th Papers July 12th - Tuesday Singh, J.; Chuaqui, C.; Boriack-Sjodin, P.; Lee, W.; Pontz, T.; Corbley, M.; Cheung, H.; Arduini, R.; Mead, J.; Newman, M.; Papadatos, J.; Bowes, S.; Josiah, S.; Ling, L., Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). **Bioorg Med Chem Lett** 2003, 13 (24), 4355-9. [|SinghVirtualTGFbetaBioorgMedChemLett2003.pdf]
 * Jeanette**

Herschhorn, A.; Hizi, A., Virtual screening, identification, and biochemical characterization of novel inhibitors of the reverse transcriptase of human immunodeficiency virus type-1. //J Med Chem// **2008,** //51// (18), 5702-13. [|HerschhornHIVreversetranscriptaseVirtualScreenJMedChem2008.pdf]
 * Larry**

4th Papers July 5th - Tuesday Mochalkin, I.; Miller, J.; Narasimhan, L.; Thanabal, V.; Erdman, P.; Cox, P.; Prasad, J.; Lightle, S.; Huband, M.; Stover, C., Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches. ACS Chem Biol 2009, 4 (6), 473-83. [|MochalkinVirtualScreeningBiotinCarboxylaseFASII_ACSCHemBiol2009.pdf]
 * Krishna**

3rd Papers June 28th - Tuesday  Bai, Y.; Monzingo, A.; Robertus, J., The X-ray structure of ricin A chain with a novel inhibitor. //Arch Biochem Biophys// **2009,** //483// (1), 23-8.
 * Sadhana**

[|BaiRicinVirtualScreenToxicon2010.pdf]


 * Christina**

Cho, Y.; Ioerger, T.; Sacchettini, J., Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. //J Med Chem// **2008,** //51// (19), 5984-92. [|ChoSacchettiniVirtualScreening_TB_HisG_JMedChem2008.pdf]

2nd Papers June 21st - Tuesday Park, H.; Kim, Y. J.; Hahn, J. S., A novel class of Hsp90 inhibitors isolated by structure-based virtual screening. //Bioorganic & Medicinal Chemistry Letters// **2007,** //17// (22), 6345-6349. [|ParkHsp90drugVirtualScreenBioorgMedChemLett2007.pdf]
 * Joey**

Zhang, Y.; White, S.; Rock, C., Inhibiting bacterial fatty acid synthesis. //J Biol Chem// **2006,** //281// (26), 17541-4. [|FASII_review_jbc2006.pdf]
 * J.C.**

1st Papers June 14th - Tuesday Zolli-Juran, M.; Cechetto, J. D.; Hartlen, R.; Daigle, D. M.; Brown, E. D., High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. //Bioorganic & Medicinal Chemistry Letters// 2003, 13 (15), 2493-2496. [|Zolli_JuranDHFRbacteriaHTSBioorgMedChemLett2003.pdf]
 * Marshall**

Prasannan, P.; Suliman, H. S.; Robertus, J. D., Kinetic analysis of site-directed mutants of methionine synthase from Candida albicans. //Biochem Biophys Res Commun// **2009,** //382// (4), 730-4. [|PrasannanPriya_MetSynthaseKinetic_RobertusBiochemBiophysResComm2009.pdf]
 * Justin**